O11 - Cor a 14: the missing link in the molecular diagnosis of hazelnut allergy?

Results Thirty-seven patients suffered from a systemic reaction and 38 patients reported an oral allergy syndrome (OAS) after eating hazelnut. In the population with systemic reactions, sensitization to Cor a 14 was seen in 19/20 preschoolchildren (median age (range) 2.6 years (1.0 – 5.4)), 8/10 schoolchildren (10.2 years (8.0 – 13.8 )) and 2/7 adults (28 years (18 – 33)) whereas sensitization to Cor a 9 was observed in 16/20 preschoolchildren, 7/10 schoolchildren and 3/7 adults. A minority of 13/37 and 5/37 was sensitized to Cor a 11 and Cor a 8. Combining of Cor a 14 and Cor a 9 enables us to correctly diagnose respectively 100 %, 80 % and 43 % of systemic reactions in preschool-, schoolchildren and adults. In contrast sensitization to Cor a 1.04 was generally associated with OAS, IgE reactivity to Cor a 1.04 was observed in respectively 6/7, 8/9 and 22/22 of preschool, schoolchildren and adults. Sensitization to Cor a 14 was seen in two patients with OAS, although these sIgE levels to Cor a 14 were significantly lower. Twenty-one percent of the infants with AD showed Cor a 14 sensitization, whereas 4/14 and 1/14 showed IgE reactivity to Cor a 9 and Cor a 11.